Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23803767 | 0.89 | BTK (0.34) | BTKGSK3BDRD2DRD3 | |
| SCHEMBL23816438 | 0.89 | BTK (0.44) | BTKLCKGSK3BDRD2DRD3 | |
| SCHEMBL26115667 | 0.89 | BTK (0.34) | BTKGSK3BDRD2DRD3 | |
| SCHEMBL23816456 | 0.85 | BTK (0.39) | BTKLCKGSK3B | |
| SCHEMBL30151517 | 0.84 | BTK (0.41) | BTKLCKGSK3B | |
| SCHEMBL26112365 | 0.83 | BTK (0.36) | BTKLCKGSK3B | |
| SCHEMBL23816201 | 0.82 | BTK (0.38) | BTKLCKGSK3B | |
| SCHEMBL23816557 | 0.82 | BTK (0.43) | BTKLCKGSK3B | |
| SCHEMBL30063405 | 0.82 | BTK (0.41) | BTKLCK | |
| SCHEMBL26114267 | 0.82 | BTK (0.41) | BTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021180103-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-09-16 | — | — | WO | disclosed |