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SCHEMBL23824832

SCHEMBL23824832

CN(C)C(=O)c1ccc(N2CCC([C@H]3C[C@H]3CN(C)C(=O)C(O)(c3cc(Cl)cc(Cl)c3)C(F)(F)F)CC2)nc1Cl

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 4/20 0.41
▸ NR1H3 Q13133 4/20 0.41
▸ KCNH2 Q12809 2/20 0.32
▸ GPR119 Q8TDV5 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20072042 1.00 NR1H2 (0.41) NR1H2NR1H3KCNH2GPR119
SCHEMBL20074047 0.92 NR1H2 (0.49) NR1H2NR1H3
SCHEMBL20071857 0.92 NR1H2 (0.49) NR1H2NR1H3
SCHEMBL23824836 0.92 NR1H2 (0.49) NR1H2NR1H3
SCHEMBL20074076 0.92 NR1H2 (0.49) NR1H2NR1H3
SCHEMBL20074075 0.90 NR1H2 (0.43) NR1H2NR1H3
SCHEMBL20071860 0.90 NR1H2 (0.43) NR1H2NR1H3
SCHEMBL20072141 0.88 NR1H2 (0.42) NR1H2NR1H3
SCHEMBL21644218 0.88 NR1H2 (0.42) NR1H2NR1H3
SCHEMBL20072138 0.88 NR1H2 (0.41) NR1H2NR1H3KCNH2GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3526203-B1 N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE MERCK SHARP & DOHME (US) 2021-09-22 — — EP disclosed
EP-3526203-B1 N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE MERCK SHARP & DOHME (US) 2021-09-22 — — EP disclosed
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