SCHEMBL23827271

SCHEMBL23827271

COc1ccc(C(OC[C@@]23CN(S(C)(=O)=O)[C@@H]([C@H](n4cnc5c(=O)[nH]c(NC(=O)C(C)C)nc54)O2)[C@@H]3O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TYMP P19971 6/20 0.43
▸ KDM4E B2RXH2 1/20 0.39
▸ TAS1R3 Q7RTX0 1/20 0.35
▸ TAS1R1 Q7RTX1 1/20 0.35
▸ TAAR1 Q96RJ0 2/20 0.34
▸ HPGD P15428 1/20 0.33
▸ PDE9A O76083 1/20 0.33
▸ ADORA3 P0DMS8 3/20 0.32
▸ ADORA2A P29274 3/20 0.32
▸ ADORA1 P30542 3/20 0.32
▸ ADORA2B P29275 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24176894 0.95 TYMP (0.42) TYMPKDM4ETAS1R3TAS1R1TAAR1
SCHEMBL23827249 0.93 TYMP (0.40) TYMPKDM4ETAS1R3TAS1R1TAAR1
SCHEMBL24177253 0.88 TYMP (0.39) TYMPKDM4ETAS1R3TAS1R1TAAR1
SCHEMBL23827266 0.87 TYMP (0.48) TYMPTAAR1HPGDADORA3
SCHEMBL19362152 0.86 TYMP (0.45) TYMPKDM4ETAS1R3TAS1R1TAAR1
SCHEMBL1096942 0.86 TYMP (0.45) TYMPKDM4ETAS1R3TAS1R1TAAR1
SCHEMBL24513002 0.86 TYMP (0.45) TYMPKDM4ETAS1R3TAS1R1TAAR1
SCHEMBL24177248 0.86 TYMP (0.42) TYMPTAS1R3TAS1R1HPGDADORA3
SCHEMBL23827212 0.85 KDM4E (0.35) TYMPKDM4E
SCHEMBL30898740 0.84 CDK5 (0.36) TYMPADORA3ADORA2AADORA1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12338265-B2 Crosslinked artificial nucleic acid ALNA MITSUBISHI TANABE PHARMA CORPORATION (JP) 2025-06-24 — — US claimed
CN-119119156-A Bridged artificial nucleic acid ALNA 田边三菱制药株式会社 2024-12-13 — — CN claimed
EP-4275689-A2 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA Mitsubishi Tanabe Pharma Corporation (JP) 2023-11-15 — — EP claimed
US-20220002336-A1 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA MITSUBISHI TANABE PHARMA CORPORATION (JP) 2022-01-06 — — US claimed
EP-3881851-A1 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA Mitsubishi Tanabe Pharma Corporation (JP) 2021-09-22 — — EP claimed
US-20250340584-A1 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA MITSUBISHI TANABE PHARMA CORPORATION (JP) 2025-11-06 — — US disclosed
US-12338265-B2 Crosslinked artificial nucleic acid ALNA MITSUBISHI TANABE PHARMA CORPORATION (JP) 2025-06-24 — — US disclosed
CN-119119156-A Bridged artificial nucleic acid ALNA 田边三菱制药株式会社 2024-12-13 — — CN disclosed
CN-112996522-B Bridged artificial nucleic acid ALNA 田边三菱制药株式会社 2024-09-20 — — CN disclosed
CN-117964674-A Bridged artificial nucleic acid ALNA 田边三菱制药株式会社 2024-05-03 — — CN disclosed
CN-117964673-A Bridged artificial nucleic acid ALNA 田边三菱制药株式会社 2024-05-03 — — CN disclosed
EP-4275690-A2 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA Mitsubishi Tanabe Pharma Corporation (JP) 2023-11-15 — — EP disclosed
EP-4275689-A2 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA Mitsubishi Tanabe Pharma Corporation (JP) 2023-11-15 — — EP disclosed
US-20220002336-A1 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA MITSUBISHI TANABE PHARMA CORPORATION (JP) 2022-01-06 — — US disclosed
US-20220002336-A1 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA MITSUBISHI TANABE PHARMA CORPORATION (JP) 2022-01-06 — — US disclosed
EP-3881851-A1 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA Mitsubishi Tanabe Pharma Corporation (JP) 2021-09-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250340584-A1 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA POLN, DDX21, MUS81 TYMP 1322/4885KDM4E 3126/4885TAS1R3 3625/4885
US-20220002336-A1 CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA POLN, DDX21, MUS81 TYMP 1322/4885KDM4E 3126/4885TAS1R3 3625/4885
US-12338265-B2 Crosslinked artificial nucleic acid ALNA POLN, DDX21, MUS81 TYMP 1322/4885KDM4E 3126/4885TAS1R3 3625/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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