Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.73 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.73 |
| ▸ | RPS6KA6 | Q9UK32 | 4/20 | 0.59 |
| ▸ | PLK1 | P53350 | 9/20 | 0.51 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.51 |
| ▸ | PLK2 | Q9NYY3 | 8/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | TAF1 | P21675 | 2/20 | 0.48 |
| ▸ | STK4 | Q13043 | 1/20 | 0.47 |
| ▸ | VRK2 | Q86Y07 | 2/20 | 0.47 |
| ▸ | VRK1 | Q99986 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.47 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21683297 | 1.00 | PIP4K2A (0.73) | PIP4K2APIP4K2BRPS6KA6PLK1MAPK7 | |
| SCHEMBL23828194 | 0.89 | RPS6KA6 (0.60) | PIP4K2APIP4K2BRPS6KA6PLK1MAPK7 | |
| SCHEMBL23828196 | 0.89 | RPS6KA6 (0.60) | PIP4K2APIP4K2BRPS6KA6PLK1MAPK7 | |
| SCHEMBL21683193 | 0.88 | PIP4K2A (0.80) | PIP4K2APIP4K2BRPS6KA6PLK1PLK3 | |
| SCHEMBL21683191 | 0.88 | PIP4K2A (0.80) | PIP4K2APIP4K2BRPS6KA6PLK1PLK3 | |
| SCHEMBL21683182 | 0.85 | PIP4K2A (1.00) | PIP4K2APIP4K2BRPS6KA6PLK1MAPK7 | |
| SCHEMBL21683184 | 0.85 | PIP4K2A (1.00) | PIP4K2APIP4K2BRPS6KA6PLK1MAPK7 | |
| SCHEMBL23828198 | 0.84 | PIP4K2A (0.98) | PIP4K2APIP4K2BRPS6KA6PLK1MAPK7 | |
| SCHEMBL23828200 | 0.84 | PIP4K2A (0.98) | PIP4K2APIP4K2BRPS6KA6PLK1MAPK7 | |
| SCHEMBL23828195 | 0.84 | PIP4K2A (0.80) | PIP4K2APIP4K2BRPS6KA6PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773096-B2 | Small-molecule PI5P4K alpha/beta inhibitors and methods of treatment using same | YALE UNIVERSITY (US) | 2023-10-03 | — | — | US | disclosed |
| US-20210292326-A1 | Small-Molecule PI5P4K alpha/beta Inhibitors and Methods of Treatment Using Same | UNIV YALE (US) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773096-B2 | Small-molecule PI5P4K alpha/beta inhibitors and methods of treatment using same | PI4KB, TP53, PI4K2B | PIP4K2A 10/4885PIP4K2B 9/4885RPS6KA6 294/4885 |
| US-20210292326-A1 | Small-Molecule PI5P4K alpha/beta Inhibitors and Methods of Treatment Using Same | PI4KB, TP53, PI4K2B | PIP4K2A 10/4885PIP4K2B 9/4885RPS6KA6 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.