Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.56 |
| ▸ | TYK2 | P29597 | 18/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12294920 | 0.85 | TYK2 (0.57) | JAK2TYK2CDK2JAK1CDK9 | |
| SCHEMBL2372525 | 0.84 | TYK2 (0.58) | JAK2TYK2CDK2JAK1CDK9 | |
| SCHEMBL2371779 | 0.84 | JAK2 (0.60) | JAK2TYK2CDK2CCNA2CCNA1 | |
| SCHEMBL12295360 | 0.84 | JAK2 (0.60) | JAK2TYK2 | |
| SCHEMBL2371815 | 0.83 | TYK2 (0.53) | JAK2TYK2CDK2CCNA2CCNA1 | |
| SCHEMBL2371764 | 0.82 | TYK2 (0.43) | JAK2TYK2CDK2JAK1CDK9 | |
| SCHEMBL14858434 | 0.82 | TYK2 (0.48) | JAK2TYK2CDK2JAK1CDK9 | |
| SCHEMBL12294570 | 0.80 | TYK2 (0.47) | JAK2TYK2CDK2JAK1CDK9 | |
| SCHEMBL14858365 | 0.77 | JAK2 (0.47) | JAK2TYK2CDK9 | |
| SCHEMBL2372568 | 0.77 | TYK2 (0.48) | JAK2TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547338-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011113802-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-22 | — | — | WO | disclosed |