SCHEMBL23831747

SCHEMBL23831747

O=C(Nc1cc(Cl)cc(Cl)c1)Nc1cc(Cl)cc(Cl)c1CCO

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
P2RY1 P47900 1/20 0.49
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
MAPT P10636 3/20 0.47
RAB9A P51151 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
DHODH Q02127 1/20 0.47
TRPV1 Q8NER1 3/20 0.46
LMNA P02545 2/20 0.41
ALDH1A1 P00352 2/20 0.41
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30105153 1.00 P2RY1 (0.49) P2RY1MEN1KMT2AMAPTRAB9A
SCHEMBL30105328 0.91 TRPV1 (0.44) P2RY1MEN1KMT2AMAPTRAB9A
SCHEMBL30105231 0.91 TRPV1 (0.42) P2RY1MEN1KMT2AMAPTRAB9A
SCHEMBL23831903 0.91 TRPV1 (0.42) P2RY1MEN1KMT2AMAPTRAB9A
SCHEMBL23832041 0.91 TRPV1 (0.44) P2RY1MEN1KMT2AMAPTRAB9A
SCHEMBL23831945 0.90 TRPV1 (0.43) P2RY1MEN1KMT2AMAPTRAB9A
SCHEMBL30105070 0.90 TRPV1 (0.43) P2RY1MEN1KMT2AMAPTRAB9A
SCHEMBL23831866 0.89 TRPV1 (0.45) P2RY1MEN1KMT2AMAPTRAB9A
SCHEMBL23831932 0.89 S1PR2 (0.55) P2RY1MEN1KMT2AMAPTRAB9A
SCHEMBL27077608 0.89 TRPV1 (0.42) P2RY1MEN1KMT2AMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121415-B1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES UNIV PALACKEHO (CZ) 2024-02-07 EP disclosed
EP-4121415-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES Univerzita Palackého v Olomouci (CZ) 2023-01-25 EP disclosed
WO-2021185391-A1 INHIBITORS OF CYTOKININ OXIDASE DERIVED FROM 1-[2-(HYDROXYALKYL)PHENYL]-3-YLUREA, USE THEREOF AND PREPARATIONS CONTAINING THESE DERIVATIVES UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2021-09-23 WO disclosed