Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PEPD | P12955 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2262043 | 1.00 | ACE (0.55) | ACEKMT2ARAB9ACMA1MAPK1 | |
| SCHEMBL10935144 | 1.00 | ACE (0.55) | ACEKMT2ARAB9ACMA1MAPK1 | |
| SCHEMBL9510956 | 0.90 | KMT2A (0.52) | ACEKMT2ACMA1MAPK1LMNA | |
| SCHEMBL22070275 | 0.88 | ACE (0.57) | ACECMA1RENLMNAKDM4E | |
| SCHEMBL6242285 | 0.88 | ACE (0.57) | ACECMA1RENLMNAKDM4E | |
| SCHEMBL22070276 | 0.88 | ACE (0.57) | ACECMA1RENLMNAKDM4E | |
| SCHEMBL7563228 | 0.87 | ACE (0.56) | ACECMA1RENLMNAKDM4E | |
| SCHEMBL20174030 | 0.87 | ACE (0.67) | ACECMA1MAPK1RENF2 | |
| SCHEMBL13667609 | 0.86 | ACE (0.55) | ACECMA1RENLMNAKDM4E | |
| SCHEMBL23795536 | 0.86 | ACE (0.55) | ACECMA1RENLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121055-A1 | STAT DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| WO-2021188696-A1 | STAT DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |