⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31185706 | 0.71 | — | — | |
| SCHEMBL4696439 | 0.62 | — | — | |
| SCHEMBL4486855 | 0.61 | — | — | |
| SCHEMBL23833208 | 0.60 | — | — | |
| SCHEMBL23833213 | 0.60 | — | — | |
| SCHEMBL19750859 | 0.58 | TSHR (0.35) | — | |
| SCHEMBL4899176 | 0.56 | — | — | |
| SCHEMBL7856939 | 0.56 | — | — | |
| SCHEMBL4637663 | 0.55 | — | — | |
| SCHEMBL27586179 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240016942-A1 | STAT DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2024-01-18 | — | — | US | disclosed |
| CN-117126231-A | Peptoid STAT protein degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-116490069-A | STAT degradation agent and application thereof | 凯麦拉医疗公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-115776891-A | STAT degradants and uses thereof | 凯麦拉医疗公司 | 2023-03-10 | — | — | CN | disclosed |
| EP-4121055-A1 | STAT DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| CN-114269763-A | Small molecule degradant for STAT3 | 美国密歇根州立大学试剂中心 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021188696-A1 | STAT DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| CN-107709305-B | Novel compound | 葛兰素史克知识产权开发有限公司 | 2020-09-29 | — | — | CN | disclosed |