Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 14/20 | 0.36 |
| ▸ | AKT2 | P31751 | 14/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL238379 | 1.00 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL2755300 | 1.00 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL237947 | 0.94 | AKT1 (0.41) | AKT1AKT2 | |
| SCHEMBL238318 | 0.94 | AKT1 (0.41) | AKT1AKT2 | |
| SCHEMBL238585 | 0.94 | AKT1 (0.41) | AKT1AKT2 | |
| SCHEMBL237057 | 0.93 | AKT1 (0.34) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL2755303 | 0.93 | AKT1 (0.34) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL237791 | 0.92 | AKT1 (0.33) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL16986796 | 0.92 | AKT1 (0.36) | AKT1AKT2 | |
| SCHEMBL16986795 | 0.92 | AKT1 (0.36) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614221-B2 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. (US) | 2013-12-24 | — | — | US | disclosed |
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3R5 | NPC1 1127/4885RAB9A 778/4885SMN1; SMN2 3442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.