SCHEMBL238389

SCHEMBL238389

CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)NS(=O)(=O)c3ccccc3)cc1)C2

nearest known ligand 0.79

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 20/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29508251 1.00 PTGER4 (0.79) PTGER4
SCHEMBL5397220 0.93 PTGER4 (0.72) PTGER4
SCHEMBL5223597 0.89 PTGER4 (1.00) PTGER4
SCHEMBL2300769 0.85 PTGER4 (1.00) PTGER4
SCHEMBL5221211 0.84 PTGER4 (0.87) PTGER4
SCHEMBL1735898 0.81 PTGER4 (0.85) PTGER4
SCHEMBL3567548 0.81 PTGER4 (0.94) PTGER4
SCHEMBL3561049 0.81 PTGER4 (0.94) PTGER4
SCHEMBL3561068 0.80 PTGER4 (0.90) PTGER4
SCHEMBL3567596 0.80 PTGER4 (0.90) PTGER4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160030478-A1 MATERIALS AND METHODS TO ENHANCE HEMATOPOIETIC STEM CELLS ENGRAFTMENT PROCEDURES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION 2016-02-04 US claimed
EP-2555774-B1 Medicine combinations containing pde4 inhibitors and ep4 receptor antagonists BOEHRINGER INGELHEIM INT (DE) 2015-10-21 EP claimed
US-20140377214-A1 MATERIALS AND METHODS TO ENHANCE HEMATOPOIETIC STEM CELLS ENGRAFTMENT PROCEDURES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION 2014-12-25 US claimed
US-8877758-B2 Combinations of medicaments, containing PDE4-inhibitors and EP4-receptor-antagonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-11-04 US claimed
US-20140065706-A1 MATERIALS AND METHODS FOR MOBILIZING CELLS INCLUDING CD34+, HEMATOPOIETIC COLONY FORMING, AND ENDOTHELIAL COLONY FORMING CELLS INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) 2014-03-06 US claimed
US-20140017339-A1 MATERIALS AND METHODS FOR TREATING RADIATION POISONING INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) 2014-01-16 US claimed
US-20130237527-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-09-12 US claimed
US-20130225609-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-08-29 US claimed
EP-2555773-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4 INHIBITORS AND EP4 RECEPTOR ANTAGONISTS Boehringer Ingelheim International GmbH (DE) 2013-02-13 EP claimed
EP-2555774-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4 INHIBITORS AND EP4 RECEPTOR ANTAGONISTS Boehringer Ingelheim International GmbH (DE) 2013-02-13 EP claimed
WO-2012061820-A2 MATERIALS AND METHODS FOR TREATING RADIATION POISONING INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2012-05-10 WO claimed
WO-2012061822-A2 MATERIALS AND METHODS FOR MOBILIZING CELLS INCLUDING CD34+, HEMATOPOIETIC COLONY FORMING, AND ENDOTHELIAL COLONY FORMING CELLS INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2012-05-10 WO claimed
US-20120003189-A1 Materials and Methods to Enhance Hematopoietic Stem Cells Engraftment Procedures INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2012-01-05 US claimed
WO-2011124524-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4 INHIBITORS AND EP4 RECEPTOR ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-10-13 WO claimed
WO-2011124525-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4 INHIBITORS AND EP4 RECEPTOR ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-10-13 WO claimed
EP-2362733-A1 MATERIALS AND METHODS TO ENHANCE HEMATOPOIETIC STEM CELLS ENGRAFTMENT PROCEDURES Indiana University Research Technology Corporation (US) 2011-09-07 EP claimed
WO-2010054271-A1 MATERIALS AND METHDS TO ENHANCE HEMATOPOIETIC STEM CELLS ENGRAFTMENT PROCEDURES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2010-05-14 WO claimed
US-20040087624-A1 Benzo (f) insoindol derivatives and their use as ep4 receptor ligands GLAXO GROUP LIMITED (GB) 2004-05-06 US claimed
EP-3824884-A1 MATERIALS AND METHODS TO ENHANCE HEMATOPOIETIC STEM CELLS ENGRAFTMENT PROCEDURES Indiana University Research and Technology Corporation (US) 2021-05-26 EP disclosed
US-20040087624-A1 Benzo (f) insoindol derivatives and their use as ep4 receptor ligands GLAXO GROUP LIMITED (GB) 2004-05-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130225609-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS PTGER4, PTGER1, PDE4A PTGER4 1/4885
US-20040087624-A1 Benzo (f) insoindol derivatives and their use as ep4 receptor ligands PTGER4, PTGER1, OPRL1 PTGER4 1/4885
US-20130237527-A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS PTGER4, PTGER1, PTGER3 PTGER4 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.