Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | HSPA8 | P11142 | 5/20 | 0.83 |
| ▸ | CDK2 | P24941 | 3/20 | 0.74 |
| ▸ | CDK1 | P06493 | 2/20 | 0.74 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.74 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.74 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.74 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.57 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.53 |
| ▸ | ADK | P55263 | 4/20 | 0.52 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384317 | 1.00 | HIF1A (1.00) | HIF1AHSPA8CDK2CDK1CCNA2 | |
| SCHEMBL12284814 | 1.00 | HIF1A (1.00) | HIF1AHSPA8CDK2CDK1CCNA2 | |
| SCHEMBL29780006 | 1.00 | HIF1A (1.00) | HIF1AHSPA8CDK2CDK1CCNA2 | |
| SCHEMBL20141370 | 0.90 | HIF1A (0.81) | HIF1AHSPA8CDK2CDK1CCNA2 | |
| SCHEMBL22111064 | 0.90 | HIF1A (0.81) | HIF1AHSPA8CDK2CDK1CCNA2 | |
| SCHEMBL20141362 | 0.88 | HIF1A (0.79) | HIF1AHSPA8CDK2CDK1CCNA2 | |
| SCHEMBL22111053 | 0.87 | HIF1A (0.77) | HIF1AHSPA8CDK2CDK1CCNA2 | |
| SCHEMBL30131081 | 0.87 | HIF1A (0.77) | HIF1AHSPA8CDK2CDK1CCNA2 | |
| SCHEMBL20141988 | 0.87 | HIF1A (0.77) | HIF1AHSPA8CDK2CDK1CCNA2 | |
| SCHEMBL20141359 | 0.86 | HIF1A (0.75) | HIF1AHSPA8CDK2CDK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214670-A2 | COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION | Taiga Biotechnologies, Inc. (US) | 2010-08-11 | — | — | EP | claimed |
| WO-2009059304-A2 | COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION | TAIGA BIOTECHNOLOGIES, INC. (US) | 2009-05-07 | — | — | WO | claimed |
| US-20110218210-A1 | COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION | Taiga Biotechnologies (US) | 2011-09-08 | — | — | US | disclosed |
| EP-2214670-A2 | COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION | Taiga Biotechnologies, Inc. (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009059304-A2 | COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION | TAIGA BIOTECHNOLOGIES, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218210-A1 | COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION | MKI67, PCNA, CCNC | HIF1A 1802/4885HSPA8 2025/4885CDK2 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.