Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 9/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10118804 | 0.89 | HRH3 (0.49) | HRH3ALDH1A1LMNAL3MBTL1HPGD | |
| SCHEMBL19368254 | 0.83 | NOTUM (0.51) | HRH3NOTUMALDH1A1LMNAKDM4E | |
| SCHEMBL23844510 | 0.82 | NOTUM (0.50) | NOTUMALDH1A1L3MBTL1ACACBKDM4E | |
| SCHEMBL25016625 | 0.81 | HRH3 (0.45) | HRH3NOTUMALDH1A1LMNAL3MBTL1 | |
| SCHEMBL25017269 | 0.81 | HRH3 (0.45) | HRH3NOTUMALDH1A1LMNAL3MBTL1 | |
| SCHEMBL24352429 | 0.79 | CCR6 (0.49) | HRH3NOTUMALDH1A1LMNAACACB | |
| SCHEMBL24352423 | 0.79 | CCR6 (0.49) | HRH3NOTUMALDH1A1LMNAACACB | |
| SCHEMBL23959393 | 0.79 | HRH4 (0.46) | HRH3NOTUMALDH1A1L3MBTL1ACACB | |
| SCHEMBL23844192 | 0.79 | MCHR1 (0.48) | ALDH1A1KMT2A | |
| SCHEMBL24481511 | 0.79 | NOTUM (0.55) | NOTUMLMNAL3MBTL1MAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169631-A9 | TAIRE FAMILY KINASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-06-02 | — | — | US | disclosed |
| US-20210292299-A1 | TAIRE FAMILY KINASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169631-A9 | TAIRE FAMILY KINASE INHIBITORS AND USES THEREOF | CDK14, CDK16, CDK19 | HRH3 3055/4885NOTUM 3306/4885ALDH1A1 4421/4885 |
| US-20210292299-A1 | TAIRE FAMILY KINASE INHIBITORS AND USES THEREOF | CDK14, CDK16, CDK19 | HRH3 3055/4885NOTUM 3306/4885ALDH1A1 4421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.