Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 16/20 | 0.89 |
| ▸ | PMAIP1 | Q13794 | 15/20 | 0.89 |
| ▸ | BAD | Q92934 | 11/20 | 0.89 |
| ▸ | BCL2L1 | Q07817 | 8/20 | 0.89 |
| ▸ | BCL2 | P10415 | 7/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23844560 | 0.94 | MCL1 (0.89) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL22437569 | 0.94 | MCL1 (1.00) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL23844578 | 0.94 | MCL1 (0.88) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL23844575 | 0.94 | MCL1 (0.88) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL22437449 | 0.92 | BAD (0.75) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL23786363 | 0.92 | MCL1 (0.77) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL23844469 | 0.91 | MCL1 (0.90) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL23844490 | 0.89 | MCL1 (0.88) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL23844502 | 0.89 | MCL1 (0.88) | MCL1PMAIP1BADBCL2L1BCL2 | |
| SCHEMBL23781471 | 0.89 | BAD (0.74) | MCL1PMAIP1BADBCL2L1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210292341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210292341-A1 | MACROCYCLIC INDOLE DERIVATIVES | CCND2, CCNA1, CCNT2 | MCL1 56/4885PMAIP1 1324/4885BAD 332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.