Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877991 | 0.83 | CYSLTR1 (0.52) | CYP1A2CYSLTR1CYSLTR2PDE10ANCF1 | |
| SCHEMBL14086502 | 0.81 | PDE10A (0.50) | CYP1A2CYSLTR1CYSLTR2PDE10ACYP3A4 | |
| SCHEMBL7085590 | 0.80 | CYSLTR1 (0.49) | CYP1A2CYSLTR1CYSLTR2PDE10ACYP2E1 | |
| SCHEMBL5594068 | 0.79 | CYP1A2 (0.45) | CYP1A2CYSLTR1CYSLTR2PDE10ACYP2E1 | |
| SCHEMBL3704591 | 0.78 | CYSLTR1 (0.51) | CYP1A2CYSLTR1CYSLTR2PDE10ACYP2E1 | |
| SCHEMBL20228144 | 0.78 | PDE10A (0.48) | CYP1A2CYSLTR1CYSLTR2PDE10ACYP3A4 | |
| SCHEMBL5594071 | 0.77 | CYSLTR1 (0.46) | CYP1A2CYSLTR1CYSLTR2PDE10ACYP2E1 | |
| SCHEMBL10546745 | 0.77 | CYSLTR2 (0.50) | CYP1A2CYSLTR1CYSLTR2PDE10ACYP2E1 | |
| SCHEMBL153778 | 0.77 | CYSLTR1 (0.53) | CYP1A2CYSLTR1CYSLTR2PDE10ANCF1 | |
| SCHEMBL29405396 | 0.77 | CYSLTR1 (0.53) | CYP1A2CYSLTR1CYSLTR2PDE10ANCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210292300-A1 | DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210292300-A1 | DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS | TLR9, TLR7, TLR8 | CYP1A2 3926/4885CYSLTR1 326/4885CYSLTR2 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.