Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.50 |
| ▸ | CTSD | P07339 | 15/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372194 | 0.82 | BACE1 (0.48) | BACE1CTSDKCNH2 | |
| SCHEMBL3280202 | 0.82 | BACE1 (0.54) | BACE1CTSDKCNH2 | |
| SCHEMBL2370976 | 0.82 | BACE1 (0.58) | BACE1CTSDKCNH2 | |
| SCHEMBL3273268 | 0.79 | BACE1 (0.51) | BACE1CTSDKCNH2 | |
| SCHEMBL2371257 | 0.78 | BACE1 (0.54) | BACE1CTSDKCNH2 | |
| SCHEMBL2517693 | 0.78 | BACE1 (0.55) | BACE1CTSDKCNH2 | |
| SCHEMBL3273601 | 0.76 | BACE1 (0.50) | BACE1CTSD | |
| SCHEMBL2522777 | 0.76 | BACE1 (0.52) | BACE1CTSDKCNH2 | |
| SCHEMBL3278041 | 0.75 | BACE1 (0.52) | BACE1CTSDKCNH2 | |
| SCHEMBL2524041 | 0.75 | BACE1 (0.48) | BACE1CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |