Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 6/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 6/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25099945 | 0.77 | PIK3CA (0.51) | MTORPIK3CAPIK3CBATRATRIP | |
| SCHEMBL30233112 | 0.77 | PIK3CA (0.51) | MTORPIK3CAPIK3CBATRATRIP | |
| SCHEMBL20797900 | 0.75 | ATR (0.44) | MTORPIK3CAATRATRIPCHEK1 | |
| SCHEMBL20797898 | 0.75 | ATR (0.44) | MTORPIK3CAATRATRIPCHEK1 | |
| SCHEMBL22160812 | 0.75 | ATR (0.44) | MTORPIK3CAATRATRIPCHEK1 | |
| SCHEMBL29261326 | 0.75 | PIK3CA (0.51) | MTORPIK3CAATRATRIPCHEK1 | |
| SCHEMBL29261233 | 0.75 | PIK3CA (0.51) | MTORPIK3CAATRATRIPCHEK1 | |
| SCHEMBL738648 | 0.75 | ATR (0.47) | MTORPIK3CAATRATRIPCHEK1 | |
| SCHEMBL2492704 | 0.75 | ATR (0.47) | MTORPIK3CAATRATRIPCHEK1 | |
| SCHEMBL2487867 | 0.75 | ATR (0.47) | MTORPIK3CAATRATRIPCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021189036-A1 | TAF1 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2021-09-23 | — | — | WO | disclosed |