Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.50 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | JAK1 | P23458 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21493320 | 0.88 | TYK2 (0.47) | TYK2JAK2JAK1KCNH2KIT | |
| SCHEMBL23849706 | 0.88 | TYK2 (0.65) | TYK2JAK2JAK1KCNH2KIT | |
| SCHEMBL20093260 | 0.88 | TYK2 (0.54) | TYK2 | |
| SCHEMBL21493382 | 0.88 | TYK2 (0.57) | TYK2JAK2JAK1 | |
| SCHEMBL21493372 | 0.87 | TYK2 (0.44) | TYK2JAK2JAK1KCNH2KIT | |
| SCHEMBL21493307 | 0.86 | TYK2 (0.66) | TYK2JAK2JAK1KCNH2KIT | |
| SCHEMBL20112997 | 0.86 | TYK2 (0.60) | TYK2JAK2JAK1KCNH2KIT | |
| SCHEMBL29707508 | 0.86 | TYK2 (0.60) | TYK2JAK2JAK1KCNH2KIT | |
| SCHEMBL23849736 | 0.85 | TYK2 (0.57) | TYK2 | |
| SCHEMBL21493338 | 0.85 | TYK2 (0.63) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532473-B1 | HETEROBICYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2021-09-29 | — | — | EP | disclosed |