Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 7/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2383496 | 0.91 | P2RY12 (0.44) | PI4KBP2RY12PDGFRBMAPTMAPK1 | |
| SCHEMBL2385769 | 0.90 | PDGFRB (0.44) | PI4KBP2RY12PDGFRBLIMK2MAPT | |
| SCHEMBL2384210 | 0.86 | PI4KB (0.43) | PI4KBP2RY12PDGFRBLIMK2MAPT | |
| SCHEMBL2384230 | 0.86 | MAPT (0.55) | PI4KBMAPTMAPK1L3MBTL1 | |
| SCHEMBL2381564 | 0.86 | P2RY12 (0.45) | PI4KBP2RY12PDGFRBLIMK2 | |
| SCHEMBL2384924 | 0.85 | PI4KB (0.44) | PI4KBP2RY12PDGFRBLIMK2MAPT | |
| SCHEMBL2716171 | 0.84 | PDGFRB (0.45) | PI4KBPDGFRBLIMK2MAPTMAPK1 | |
| SCHEMBL2384868 | 0.84 | PDGFRB (0.45) | PDGFRBMAPT | |
| SCHEMBL2385316 | 0.83 | NR2E1 (0.47) | MAPT | |
| SCHEMBL2717511 | 0.82 | PI4KB (0.53) | PI4KBP2RY12LIMK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013156-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | claimed |
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2007-11-29 | — | — | US | claimed |
| US-8013156-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-8013156-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-8013156-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2007-11-29 | — | — | US | disclosed |
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2007-11-29 | — | — | US | disclosed |
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | TIE1, TEK, KDR | PI4KB 213/4885P2RY12 1298/4885PDGFRB 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.