⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28139936 | 0.90 | TSHR (0.38) | — | |
| SCHEMBL1874859 | 0.87 | CYP2C19 (0.36) | — | |
| SCHEMBL27578341 | 0.80 | FFAR3 (0.35) | — | |
| SCHEMBL585224 | 0.75 | TSHR (0.36) | — | |
| SCHEMBL15085805 | 0.72 | — | — | |
| SCHEMBL27620406 | 0.70 | SLC7A5 (0.48) | — | |
| SCHEMBL17867349 | 0.70 | — | — | |
| SCHEMBL12333137 | 0.70 | — | — | |
| SCHEMBL9723832 | 0.70 | FFAR3 (0.38) | — | |
| SCHEMBL12634606 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109898-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2024-04-04 | — | — | US | disclosed |
| EP-4282868-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVE, AND COMPOSITIONS AND MEDICAL USE THEREOF | Shanghai Haiyan Pharmaceutical Technology Co., Ltd (CN) | 2023-11-29 | — | — | EP | disclosed |
| CN-116761609-A | Substituted pyrazolo [1,5-a ] pyrimidin-7-amine derivatives, compositions thereof and pharmaceutical uses thereof | 上海海雁医药科技有限公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-4204393-A1 | AMINOCARBAMOYL COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS | F. Hoffmann-La Roche AG (CH) | 2023-07-05 | — | — | EP | disclosed |
| CN-111138366-B | Pyrazole carbamoyl derivatives, preparation method and application thereof | 天津药物研究院有限公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2022156779-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVE, AND COMPOSITIONS AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2022-07-28 | — | — | WO | disclosed |
| EP-3883918-A1 | RIP1 INHIBITORS | Sironax Ltd (KY) | 2021-09-29 | — | — | EP | disclosed |
| CN-111138366-A | Pyrazole carbamoyl derivatives, preparation method and application thereof | 天津药物研究院有限公司 | 2020-05-12 | — | — | CN | disclosed |