Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 10/20 | 0.74 |
| ▸ | SRC | P12931 | 6/20 | 0.74 |
| ▸ | FLT3 | P36888 | 6/20 | 0.74 |
| ▸ | TEK | Q02763 | 4/20 | 0.74 |
| ▸ | ABL1 | P00519 | 4/20 | 0.74 |
| ▸ | EGFR | P00533 | 4/20 | 0.74 |
| ▸ | LCK | P06239 | 3/20 | 0.74 |
| ▸ | RET | P07949 | 2/20 | 0.74 |
| ▸ | KDR | P35968 | 2/20 | 0.74 |
| ▸ | PLK4 | O00444 | 1/20 | 0.74 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.74 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.74 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.74 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.74 |
| ▸ | PAK4 | O96013 | 1/20 | 0.74 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.74 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.74 |
| ▸ | INSR | P06213 | 1/20 | 0.74 |
| ▸ | FYN | P06241 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23854987 | 1.00 | HCK (0.74) | HCKSRCFLT3TEKABL1 | |
| SCHEMBL6460275 | 0.87 | HCK (0.66) | HCKSRCFLT3TEKABL1 | |
| SCHEMBL6458138 | 0.87 | HCK (0.66) | HCKSRCFLT3TEKABL1 | |
| SCHEMBL6458140 | 0.87 | HCK (0.66) | HCKSRCFLT3TEKABL1 | |
| SCHEMBL6870684 | 0.86 | SRC (0.77) | HCKSRCFLT3TEKABL1 | |
| SCHEMBL23847632 | 0.86 | SRC (0.76) | HCKSRCFLT3TEKABL1 | |
| SCHEMBL16752301 | 0.85 | SRC (0.77) | HCKSRCFLT3TEKABL1 | |
| SCHEMBL16752298 | 0.85 | SRC (0.77) | HCKSRCFLT3TEKABL1 | |
| SCHEMBL23847633 | 0.85 | SRC (0.74) | HCKSRCFLT3TEKABL1 | |
| SCHEMBL16752234 | 0.85 | SRC (0.69) | HCKSRCFLT3TEKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210299128-A1 | COMPOUNDS FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA | RIKEN (JP) | 2021-09-30 | — | — | US | disclosed |
| US-20210299128-A1 | COMPOUNDS FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA | RIKEN (JP) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210299128-A1 | COMPOUNDS FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA | MCL1, FLT3, ABL1 | HCK 1658/4885SRC 95/4885FLT3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.