Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21661233 | 1.00 | TLR8 (0.42) | TLR8GRM1ELANEKCNMA1TLR9 | |
| SCHEMBL21661231 | 1.00 | TLR8 (0.42) | TLR8GRM1ELANEKCNMA1TLR9 | |
| SCHEMBL21645126 | 0.86 | TLR8 (0.58) | TLR8ELANETLR9TLR7 | |
| SCHEMBL21645129 | 0.86 | TLR8 (0.58) | TLR8ELANETLR9TLR7 | |
| SCHEMBL21645127 | 0.86 | TLR8 (0.58) | TLR8ELANETLR9TLR7 | |
| SCHEMBL21661048 | 0.85 | TSHR (0.38) | TLR8GRM1ELANETLR9TLR7 | |
| SCHEMBL21645078 | 0.85 | TSHR (0.38) | TLR8GRM1ELANETLR9TLR7 | |
| SCHEMBL21645169 | 0.85 | TLR8 (0.41) | TLR8GRM1ELANEKCNMA1 | |
| SCHEMBL21645176 | 0.85 | TLR8 (0.41) | TLR8GRM1ELANEKCNMA1 | |
| SCHEMBL21645173 | 0.85 | TLR8 (0.41) | TLR8GRM1ELANEKCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300940-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | TLR8 2/4885GRM1 299/4885ELANE 2732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.