Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 10/20 | 0.76 |
| ▸ | STAT1 | P42224 | 1/20 | 0.76 |
| ▸ | STAT4 | Q14765 | 1/20 | 0.76 |
| ▸ | STAT5A | P42229 | 2/20 | 0.53 |
| ▸ | STAT5B | P51692 | 2/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.52 |
| ▸ | XIAP | P98170 | 4/20 | 0.37 |
| ▸ | BIRC3 | Q13489 | 4/20 | 0.37 |
| ▸ | BIRC2 | Q13490 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23859973 | 1.00 | STAT3 (0.76) | STAT3STAT1STAT4STAT5ASTAT5B | |
| SCHEMBL22468634 | 0.95 | STAT3 (0.85) | STAT3STAT1STAT4STAT5ASTAT5B | |
| SCHEMBL22468630 | 0.95 | STAT3 (0.85) | STAT3STAT1STAT4STAT5ASTAT5B | |
| SCHEMBL25265783 | 0.94 | STAT3 (0.78) | STAT3STAT1STAT4STAT5ASTAT5B | |
| SCHEMBL25265784 | 0.94 | STAT3 (0.78) | STAT3STAT1STAT4STAT5ASTAT5B | |
| SCHEMBL25197555 | 0.94 | STAT3 (0.78) | STAT3STAT1STAT4STAT5ASTAT5B | |
| SCHEMBL30308495 | 0.94 | STAT3 (0.78) | STAT3STAT1STAT4STAT5ASTAT5B | |
| SCHEMBL23860008 | 0.94 | STAT3 (0.76) | STAT3STAT1STAT4STAT5ASTAT5B | |
| SCHEMBL23860002 | 0.94 | STAT3 (0.76) | STAT3STAT1STAT4STAT5ASTAT5B | |
| SCHEMBL23860006 | 0.94 | STAT3 (0.76) | STAT3STAT1STAT4STAT5ASTAT5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195481-A1 | SMALL MOLECULE STAT PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-09-30 | — | — | WO | disclosed |