Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 6/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.36 |
| ▸ | FAP | Q12884 | 4/20 | 0.36 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14678324 | 1.00 | HSD17B10 (0.39) | HSD17B10LMNACYP2C19DPP4DPP8 | |
| SCHEMBL3102587 | 0.90 | GABRR1 (0.34) | HSD17B10LMNACYP2C19DPP4RIPK1 | |
| SCHEMBL6476 | 0.90 | GABRR1 (0.34) | HSD17B10LMNACYP2C19DPP4RIPK1 | |
| SCHEMBL6017 | 0.90 | GABRR1 (0.34) | HSD17B10LMNACYP2C19DPP4RIPK1 | |
| SCHEMBL2273461 | 0.90 | GABRR1 (0.34) | HSD17B10LMNACYP2C19DPP4RIPK1 | |
| SCHEMBL8646401 | 0.87 | POLB (0.41) | HSD17B10LMNACYP2C19DPP4DPP8 | |
| SCHEMBL771956 | 0.87 | POLB (0.41) | HSD17B10LMNACYP2C19DPP4DPP8 | |
| SCHEMBL5469615 | 0.87 | POLB (0.41) | HSD17B10LMNACYP2C19DPP4DPP8 | |
| SCHEMBL1975621 | 0.87 | POLB (0.41) | HSD17B10LMNACYP2C19DPP4DPP8 | |
| SCHEMBL1974494 | 0.85 | HSD17B10 (0.38) | HSD17B10LMNACYP2C19DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017611-B2 | Pyridine and pyrazine derivatives -083 | ASTRAZENECA AB (SE) | 2011-09-13 | — | — | US | disclosed |
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |