Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 8/20 | 0.63 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20206223 | 1.00 | IRAK1 (0.63) | IRAK1MAP3K19IRAK4GRM5SMN1; SMN2 | |
| SCHEMBL30165336 | 1.00 | IRAK1 (0.63) | IRAK1MAP3K19IRAK4GRM5SMN1; SMN2 | |
| SCHEMBL20206130 | 1.00 | IRAK1 (0.63) | IRAK1MAP3K19IRAK4GRM5SMN1; SMN2 | |
| SCHEMBL30165339 | 0.91 | IRAK1 (0.53) | IRAK1MAP3K19IRAK4GRM5SMN1; SMN2 | |
| SCHEMBL23860709 | 0.91 | IRAK1 (0.53) | IRAK1MAP3K19IRAK4GRM5SMN1; SMN2 | |
| SCHEMBL20206103 | 0.91 | IRAK1 (0.66) | IRAK1MAP3K19IRAK4CNR2NPC1 | |
| SCHEMBL21328540 | 0.91 | IRAK1 (0.66) | IRAK1MAP3K19IRAK4CNR2NPC1 | |
| SCHEMBL20206098 | 0.90 | IRAK1 (0.71) | IRAK1MAP3K19IRAK4GRM5CNR2 | |
| SCHEMBL20206135 | 0.90 | IRAK1 (0.71) | IRAK1MAP3K19IRAK4GRM5CNR2 | |
| SCHEMBL20206097 | 0.84 | IRAK1 (0.76) | IRAK1MAP3K19IRAK4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043405-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | DANA-FARBER CANCER INSTITUTE, INC. | 2024-02-08 | — | — | US | disclosed |
| EP-4125895-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | Dana-Farber Cancer Institute, Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021194982-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043405-A1 | POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1 | IRAK1, IRAK2, IRAK3 | IRAK1 1/4885MAP3K19 86/4885IRAK4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.