Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.61 |
| ▸ | EZH1 | Q92800 | 9/20 | 0.49 |
| ▸ | EED | O75530 | 2/20 | 0.48 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.48 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.48 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.48 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.48 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.48 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17734366 | 0.95 | EZH2 (0.69) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL23863676 | 0.84 | EZH1 (0.50) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL23863645 | 0.83 | EZH2 (0.65) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL17734369 | 0.79 | EZH1 (0.55) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL17734375 | 0.78 | EZH2 (0.82) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL17734368 | 0.77 | EZH2 (0.73) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL23863720 | 0.77 | EZH2 (0.88) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL29408698 | 0.76 | EZH2 (1.00) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL17734431 | 0.76 | EZH2 (1.00) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL17734376 | 0.76 | EZH2 (0.80) | EZH2EZH1EEDRBBP4SUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3885343-A1 | INDOLE COMPOUNDS AS EZH2 INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |