Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 13/20 | 0.76 |
| ▸ | EZH1 | Q92800 | 12/20 | 0.63 |
| ▸ | EED | O75530 | 4/20 | 0.63 |
| ▸ | RBBP4 | Q09028 | 4/20 | 0.63 |
| ▸ | SUZ12 | Q15022 | 4/20 | 0.63 |
| ▸ | AEBP2 | Q6ZN18 | 4/20 | 0.63 |
| ▸ | RBBP7 | Q16576 | 3/20 | 0.63 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.63 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17734431 | 0.86 | EZH2 (1.00) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL29408698 | 0.86 | EZH2 (1.00) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL20991983 | 0.83 | EZH1 (0.70) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL24227145 | 0.81 | EZH2 (0.58) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL17734355 | 0.80 | EZH2 (0.89) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL23863720 | 0.80 | EZH2 (0.88) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL21418352 | 0.80 | EZH2 (0.68) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL10255922 | 0.78 | EZH2 (0.88) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL12180659 | 0.78 | EZH1 (1.00) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL17734470 | 0.77 | EZH2 (0.81) | EZH2EZH1EEDRBBP4SUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3885343-A1 | INDOLE COMPOUNDS AS EZH2 INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |