Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25867515 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL26594 | 0.74 | SMN1; SMN2 (0.58) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL12764464 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL14367203 | 0.72 | SMN1; SMN2 (0.41) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL23237357 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL19672707 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL2836119 | 0.69 | SMN1; SMN2 (0.62) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL7328541 | 0.69 | SMN1; SMN2 (0.62) | SMN1; SMN2CA12CA1CA9MEN1 | |
| SCHEMBL23716605 | 0.69 | SMN1; SMN2 (0.38) | SMN1; SMN2CA12CA1CA9HTT | |
| SCHEMBL20663399 | 0.69 | SMN1; SMN2 (0.38) | SMN1; SMN2CA12CA1CA9HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |