Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 20/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31741660 | 1.00 | HRH4 (0.62) | HRH4HRH3KCNH2 | |
| SCHEMBL23931246 | 0.88 | HRH4 (0.58) | HRH4HRH3 | |
| SCHEMBL30261080 | 0.88 | HRH4 (0.58) | HRH4HRH3 | |
| SCHEMBL23931247 | 0.88 | HRH4 (0.58) | HRH4HRH3 | |
| SCHEMBL23869557 | 0.85 | HRH4 (0.57) | HRH4HRH3 | |
| SCHEMBL23869428 | 0.85 | HRH4 (0.55) | HRH4HRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL31741706 | 0.85 | HRH4 (0.56) | HRH4HRH3 | |
| Hydrochloric Acid SCHEMBL31741703 | 0.85 | HRH4 (0.54) | HRH4HRH3KCNH2 | |
| SCHEMBL23869413 | 0.83 | HRH4 (0.56) | HRH4 | |
| SCHEMBL23869474 | 0.82 | HRH4 (0.65) | HRH4HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300906-A1 | PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS | NXERA PHARMA UK LIMITED (GB) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300906-A1 | PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS | HRH4, HRH3, HDAC3 | HRH4 1/4885HRH3 2/4885KCNH2 935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.