Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 11/20 | 0.56 |
| ▸ | SRC | P12931 | 10/20 | 0.56 |
| ▸ | LCK | P06239 | 10/20 | 0.56 |
| ▸ | KDR | P35968 | 10/20 | 0.56 |
| ▸ | EGFR | P00533 | 5/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | ABL2 | P42684 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005327 | 0.86 | TEK (0.76) | TEKSRCLCKKDREGFR | |
| SCHEMBL23834473 | 0.85 | TEK (0.48) | TEKSRCLCKKDREGFR | |
| SCHEMBL30143854 | 0.85 | TEK (0.48) | TEKSRCLCKKDREGFR | |
| SCHEMBL7009432 | 0.81 | SRC (0.55) | TEKSRCLCKKDREGFR | |
| SCHEMBL2074534 | 0.77 | TEK (0.64) | TEKSRCLCKKDREGFR | |
| SCHEMBL2075050 | 0.72 | KDR (0.56) | TEKSRCLCKKDREGFR | |
| SCHEMBL7005359 | 0.72 | TEK (1.00) | TEKSRCLCKKDREGFR | |
| SCHEMBL29552512 | 0.72 | TEK (1.00) | TEKSRCLCKKDREGFR | |
| SCHEMBL16752372 | 0.71 | LCK (0.59) | TEKSRCLCKKDREGFR | |
| SCHEMBL2074978 | 0.70 | KDR (0.53) | TEKSRCLCKKDRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210299128-A1 | COMPOUNDS FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA | RIKEN (JP) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210299128-A1 | COMPOUNDS FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA | MCL1, FLT3, ABL1 | TEK 622/4885SRC 95/4885LCK 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.