Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 7/20 | 0.92 |
| ▸ | CA12 | O43570 | 4/20 | 0.52 |
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | CA9 | Q16790 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1626042 | 0.96 | PTGER4 (0.87) | PTGER4CA12CA1CA2CA9 | |
| Grapiprant SCHEMBL120428 | 0.96 | PTGER4 (1.00) | PTGER4CA12CA1CA2CA9 | |
| Grapiprant SCHEMBL29496330 | 0.96 | PTGER4 (1.00) | PTGER4CA12CA1CA2CA9 | |
| SCHEMBL1624619 | 0.93 | PTGER4 (0.82) | PTGER4CA12CA1CA2CA9 | |
| SCHEMBL23089764 | 0.91 | PTGER4 (0.92) | PTGER4CA12CA1CA2CA9 | |
| SCHEMBL30225045 | 0.91 | PTGER4 (0.92) | PTGER4CA12CA1CA2CA9 | |
| SCHEMBL23876535 | 0.90 | PTGER4 (0.84) | PTGER4CA12CA1CA2CA9 | |
| SCHEMBL23876638 | 0.87 | PTGER4 (0.84) | PTGER4CA12CA1CA2CA9 | |
| SCHEMBL1624996 | 0.87 | PTGER4 (0.84) | PTGER4CA12CA1CA2CA9 | |
| SCHEMBL23109130 | 0.86 | PTGER4 (0.83) | PTGER4CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300921-A1 | EP4 INHIBITORS AND SYNTHESIS THEREOF | ASKAT INC. (JP) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300921-A1 | EP4 INHIBITORS AND SYNTHESIS THEREOF | PTGER4, EPB41, CDK4 | PTGER4 1/4885CA12 4570/4885CA1 4473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.