Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.57 |
| ▸ | TYK2 | P29597 | 13/20 | 0.57 |
| ▸ | JAK3 | P52333 | 13/20 | 0.57 |
| ▸ | JAK1 | P23458 | 11/20 | 0.57 |
| ▸ | PAK4 | O96013 | 4/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22055383 | 1.00 | JAK2 (0.57) | JAK2TYK2JAK3JAK1PAK4 | |
| SCHEMBL23878782 | 0.97 | JAK3 (0.61) | JAK2TYK2JAK3JAK1PAK4 | |
| SCHEMBL22054962 | 0.97 | JAK3 (0.61) | JAK2TYK2JAK3JAK1PAK4 | |
| SCHEMBL23889628 | 0.90 | JAK2 (0.47) | JAK2TYK2JAK3JAK1PAK4 | |
| SCHEMBL23889625 | 0.90 | JAK2 (0.47) | JAK2TYK2JAK3JAK1PAK4 | |
| SCHEMBL22054611 | 0.90 | TYK2 (0.46) | JAK2TYK2JAK3JAK1PAK4 | |
| SCHEMBL22054610 | 0.90 | TYK2 (0.46) | JAK2TYK2JAK3JAK1PAK4 | |
| SCHEMBL23878876 | 0.89 | JAK2 (0.46) | JAK2TYK2JAK3JAK1PAK4 | |
| SCHEMBL30147204 | 0.89 | TYK2 (0.48) | JAK2TYK2JAK3JAK1PAK4 | |
| SCHEMBL22055075 | 0.88 | TYK2 (0.44) | JAK2TYK2JAK3JAK1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667228-A | Salt and crystal form of heteroaromatic derivative and preparation method of salt and crystal form | 上海翰森生物医药科技有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-111511738-B | Heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-01-20 | — | — | CN | disclosed |
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |