SCHEMBL23880554

SCHEMBL23880554

O=C(O)C(=O)Nc1ccc(C#Cc2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 3/20 0.74
PTPN11 Q06124 4/20 0.71
PTPN6 P29350 3/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11428736 0.90 EPHX2 (0.68) PTPN1PTPN11PTPN6
SCHEMBL23880555 0.89 PTPN1 (0.78) PTPN1PTPN11PTPN6
SCHEMBL30042099 0.86 PTPN1 (1.00) PTPN1PTPN11PTPN6
SCHEMBL23880571 0.86 PTPN1 (1.00) PTPN1PTPN11PTPN6
SCHEMBL23880581 0.85 PTPN11 (0.76) PTPN1PTPN11PTPN6
SCHEMBL23880564 0.85 PTPN11 (0.76) PTPN1PTPN11PTPN6
SCHEMBL23895479 0.84 PTPN11 (1.00) PTPN1PTPN11PTPN6
SCHEMBL23895469 0.84 PTPN11 (0.74) PTPN1PTPN11PTPN6
SCHEMBL23880574 0.84 PTPN11 (0.64) PTPN1PTPN11PTPN6
SCHEMBL23880575 0.81 PTPN11 (0.74) PTPN1PTPN11PTPN6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115297860-B Novel N-aryl oxamic acids 普渡研究基金会 2024-10-15 CN disclosed
EP-4132523-A1 NOVEL N-ARYL OXAMIC ACIDS Purdue Research Foundation (US) 2023-02-15 EP disclosed
CN-115297860-A Novel N-aryl-oxalamic acids 普渡研究基金会 2022-11-04 CN disclosed
US-11192850-B2 N-aryl oxamic acids PURDUE RESEARCH FOUNDATION (US) 2021-12-07 US disclosed
US-20210309606-A1 Novel N-aryl Oxamic Acids PURDUE RESEARCH FOUNDATION (US) 2021-10-07 US disclosed
US-20210309606-A1 Novel N-aryl Oxamic Acids PURDUE RESEARCH FOUNDATION (US) 2021-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210309606-A1 Novel N-aryl Oxamic Acids PTPRB, PTPRO, PTPRM PTPN1 14/4885PTPN11 23/4885PTPN6 17/4885
US-11192850-B2 N-aryl oxamic acids PTPRB, PTPRO, PTPRM PTPN1 13/4885PTPN11 23/4885PTPN6 16/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.