Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.58 |
| ▸ | JAK3 | P52333 | 19/20 | 0.58 |
| ▸ | JAK2 | O60674 | 15/20 | 0.58 |
| ▸ | JAK1 | P23458 | 15/20 | 0.58 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.55 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565789 | 0.84 | TYK2 (0.52) | TYK2JAK3JAK2JAK1P2RX3 | |
| Hydrochloric Acid SCHEMBL29565580 | 0.82 | TYK2 (0.51) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL21574332 | 0.82 | TYK2 (0.71) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL24175050 | 0.81 | TYK2 (0.49) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL24175078 | 0.81 | TYK2 (0.66) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL24175232 | 0.81 | TYK2 (0.66) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL19214076 | 0.81 | TYK2 (0.71) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL24174785 | 0.81 | TYK2 (0.66) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL21676342 | 0.81 | TYK2 (0.69) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL24337003 | 0.80 | TYK2 (0.70) | TYK2JAK3JAK2JAK1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |