Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.42 |
| ▸ | JAK3 | P52333 | 13/20 | 0.42 |
| ▸ | JAK1 | P23458 | 10/20 | 0.42 |
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.35 |
| ▸ | PAK4 | O96013 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23889402 | 0.87 | TYK2 (0.46) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL24071952 | 0.85 | TYK2 (0.45) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL22055238 | 0.85 | TYK2 (0.45) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL23878807 | 0.84 | TYK2 (0.59) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL22054206 | 0.84 | TYK2 (0.59) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL22054305 | 0.79 | TYK2 (0.60) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL23879015 | 0.79 | TYK2 (0.60) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL23878737 | 0.77 | TYK2 (0.45) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL23879075 | 0.77 | TYK2 (0.59) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL22055361 | 0.77 | TYK2 (0.59) | TYK2JAK3JAK1JAK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |