Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 4/20 | 0.48 |
| ▸ | PAK4 | O96013 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 9/20 | 0.44 |
| ▸ | TYK2 | P29597 | 8/20 | 0.44 |
| ▸ | JAK3 | P52333 | 8/20 | 0.44 |
| ▸ | JAK1 | P23458 | 7/20 | 0.44 |
| ▸ | BRD4 | O60885 | 6/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 2/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24071645 | 1.00 | PLK4 (0.48) | PLK4PAK4JAK2TYK2JAK3 | |
| SCHEMBL24996491 | 0.96 | PLK4 (0.47) | PLK4PAK4JAK2TYK2JAK3 | |
| SCHEMBL22055294 | 0.92 | PLK4 (0.48) | PLK4PAK4JAK2TYK2JAK3 | |
| SCHEMBL24996503 | 0.92 | PLK4 (0.48) | PLK4PAK4JAK2TYK2JAK3 | |
| SCHEMBL22053997 | 0.90 | PLK4 (0.48) | PLK4PAK4JAK2TYK2JAK3 | |
| SCHEMBL23878876 | 0.88 | JAK2 (0.46) | PLK4PAK4JAK2TYK2JAK3 | |
| SCHEMBL30147204 | 0.88 | TYK2 (0.48) | PLK4PAK4JAK2TYK2JAK3 | |
| SCHEMBL22055317 | 0.87 | TYK2 (0.59) | PLK4PAK4JAK2TYK2JAK3 | |
| SCHEMBL22055003 | 0.87 | TYK2 (0.59) | PLK4PAK4JAK2TYK2JAK3 | |
| SCHEMBL24995391 | 0.87 | TYK2 (0.59) | PLK4PAK4JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |