Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 3/20 | 0.37 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 7/20 | 0.36 |
| ▸ | JAK2 | O60674 | 11/20 | 0.36 |
| ▸ | TYK2 | P29597 | 10/20 | 0.36 |
| ▸ | JAK3 | P52333 | 10/20 | 0.36 |
| ▸ | JAK1 | P23458 | 8/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24071963 | 0.89 | PAK1 (0.43) | PAK4BRD4JAK2TYK2JAK3 | |
| SCHEMBL30255561 | 0.89 | TYK2 (0.45) | PAK4PLK4BRD4JAK2TYK2 | |
| SCHEMBL22054952 | 0.89 | TYK2 (0.45) | PAK4PLK4BRD4JAK2TYK2 | |
| SCHEMBL23889617 | 0.87 | AURKA (0.40) | PAK4PLK4BRD4JAK2TYK2 | |
| SCHEMBL23889619 | 0.84 | PLK4 (0.39) | PAK4PLK4BRD4JAK2TYK2 | |
| SCHEMBL22054223 | 0.84 | PAK4 (0.40) | PAK4PLK4BRD4JAK2TYK2 | |
| SCHEMBL23889559 | 0.83 | PAK4 (0.41) | PAK4PLK4BRD4JAK2TYK2 | |
| SCHEMBL23889628 | 0.83 | JAK2 (0.47) | PAK4PLK4BRD4JAK2TYK2 | |
| SCHEMBL23889625 | 0.83 | JAK2 (0.47) | PAK4PLK4BRD4JAK2TYK2 | |
| SCHEMBL23889607 | 0.81 | PLK4 (0.40) | PAK4PLK4BRD4JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889152-A1 | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |