Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 18/20 | 0.76 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16659510 | 0.93 | FGFR1 (0.89) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL16659446 | 0.87 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL16659433 | 0.86 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL16655586 | 0.83 | FGFR1 (0.64) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL19732263 | 0.81 | FGFR1 (0.70) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL17728854 | 0.80 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL16654878 | 0.79 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL16655985 | 0.79 | FGFR1 (0.90) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL16659468 | 0.79 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL16659606 | 0.79 | FGFR2 (1.00) | FGFR1FGFR2FGFR3FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3421457-B1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2021-10-06 | — | — | EP | disclosed |