Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 12/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.31 |
| ▸ | CCR3 | P51677 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18571720 | 0.91 | PRMT5 (0.43) | PRMT5WDR77METTL3 | |
| SCHEMBL18572907 | 0.89 | PRMT5 (0.35) | PRMT5WDR77METTL3 | |
| SCHEMBL23892673 | 0.87 | PRMT5 (0.35) | PRMT5WDR77KCNH2HRH3CCR3 | |
| SCHEMBL23892380 | 0.86 | PRMT5 (0.37) | PRMT5WDR77METTL3 | |
| SCHEMBL23892330 | 0.85 | PRMT5 (0.34) | PRMT5WDR77METTL3 | |
| SCHEMBL18572694 | 0.82 | PRMT5 (0.36) | PRMT5WDR77METTL3 | |
| SCHEMBL23892668 | 0.81 | PRMT5 (0.32) | PRMT5WDR77SLC22A12 | |
| SCHEMBL23892519 | 0.80 | PRMT5 (0.44) | PRMT5WDR77METTL3 | |
| SCHEMBL23892707 | 0.78 | PRMT5 (0.41) | PRMT5WDR77KCNH2HRH3METTL3 | |
| SCHEMBL23892305 | 0.78 | PRMT5 (0.46) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |