Urea

Urea

SCHEMBL238973

C=CC(=O)OC(=C)CC.NC(N)=O

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 9/20 0.45
HPGD P15428 1/20 0.45
ALDH1A1 P00352 7/20 0.41
CYP3A4 P08684 2/20 0.40
FGFR4 P22455 1/20 0.36
ALOX15 P16050 1/20 0.36
TP53 P04637 3/20 0.35
HIF1A Q16665 3/20 0.35
HSD17B10 Q99714 1/20 0.35
THRB P10828 3/20 0.34
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
ATM Q13315 1/20 0.30
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3886081 0.93
SCHEMBL27629792 0.78 TSHR (0.50) TSHRHPGDALDH1A1CYP3A4TP53
Urea SCHEMBL27938736 0.77 TDP1 (0.46) TSHRHPGDALDH1A1CYP3A4FGFR4
SCHEMBL18086618 0.77 TSHR (0.46) TSHRHPGDALDH1A1CYP3A4FGFR4
SCHEMBL27902857 0.75
SCHEMBL3295058 0.74
SCHEMBL6374137 0.73
SCHEMBL23203414 0.72 TSHR (0.53) TSHRHPGDALDH1A1CYP3A4ALOX15
SCHEMBL2016426 0.72 TSHR (0.48) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL4444009 0.72 TSHR (0.48) TSHRHPGDALDH1A1CYP3A4TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748550-B2 Vinyl polymer wetting and dispersing agent VALSPAR SOURCING, INC. (US) 2014-06-10 US claimed
CN-114207059-B Two-component polyurethane compositions 陶氏环球技术有限责任公司 2023-11-07 CN disclosed
CN-112585226-B Two-component polyurethane composition 陶氏环球技术有限责任公司 2022-11-11 CN disclosed
CN-114555667-A Two-component polyurethane composition 陶氏环球技术有限责任公司 2022-05-27 CN disclosed
CN-114207059-A Two-component polyurethane composition 陶氏环球技术有限责任公司 2022-03-18 CN disclosed
CN-112585226-A Two-component polyurethane composition 陶氏环球技术有限责任公司 2021-03-30 CN disclosed
EP-2405997-B1 VINYL POLYMER WETTING AND DISPERSING AGENTS VALSPAR SOURCING INC (US) 2017-05-03 EP disclosed
US-8748550-B2 Vinyl polymer wetting and dispersing agent VALSPAR SOURCING, INC. (US) 2014-06-10 US disclosed
EP-2405997-A2 VINYL POLYMER WETTING AND DISPERSING AGENTS Valspar Sourcing, Inc. (US) 2012-01-18 EP disclosed
US-20120004359-A1 VINYL POLYMER WETTING AND DISPERSING AGENT VALSPAR SOURCING, INC. 2012-01-05 US disclosed
WO-2010105219-A2 VINYL POLYMER WETTING AND DISPERSING AGENTS VALSPAR SOURCING, INC. (US) 2010-09-16 WO disclosed