SCHEMBL23900628

SCHEMBL23900628

CNc1ccc(Oc2ccnc(-c3cnn(C)c3)c2)cn1

nearest known ligand 0.62

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 20/20 0.62
▸ KIT P10721 9/20 0.62
▸ PDGFRA P16234 8/20 0.62
▸ PDGFRB P09619 7/20 0.60
▸ MET P08581 3/20 0.59
▸ KDR P35968 3/20 0.59
▸ FLT3 P36888 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16059753 0.89 CSF1R (0.61) CSF1RKITPDGFRAPDGFRBMET
SCHEMBL23900685 0.86 CSF1R (0.61) CSF1RKITPDGFRAPDGFRBMET
SCHEMBL28341053 0.86 CSF1R (0.61) CSF1RKITPDGFRAPDGFRBMET
SCHEMBL5339036 0.85 KDR (0.58) CSF1RKITPDGFRAPDGFRBMET
SCHEMBL2416158 0.83 CSF1R (0.54) CSF1RKITPDGFRAPDGFRBMET
SCHEMBL30086949 0.83 CSF1R (0.54) CSF1RKITPDGFRAPDGFRBMET
SCHEMBL16060927 0.83 CSF1R (0.56) CSF1RKITPDGFRAPDGFRBMET
SCHEMBL22729080 0.82 CSF1R (0.68) CSF1RKITPDGFRAPDGFRBMET
SCHEMBL29736768 0.80 KDR (0.52) CSF1RKITPDGFRAPDGFRBMET
SCHEMBL574068 0.80 KDR (0.52) CSF1RKITPDGFRAPDGFRBMET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021197276-A1 Amide compounds and uses thereof HUTCHISON MEDIPHARMA LIMITED (CN) 2021-10-07 — — WO disclosed
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