Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367582 | 0.83 | KCNH2 (0.48) | KCNH2POLBALDH1A1MAPTTSHR | |
| SCHEMBL2367082 | 0.83 | KCNH2 (0.47) | KCNH2POLBALDH1A1MAPTTSHR | |
| SCHEMBL15329329 | 0.80 | KCNH2 (0.46) | KCNH2POLBALDH1A1MAPTTSHR | |
| SCHEMBL2367664 | 0.76 | MAPT (0.48) | POLBALDH1A1MAPTTSHRMEN1 | |
| SCHEMBL2367249 | 0.76 | MAPT (0.47) | POLBALDH1A1MAPTTSHRMEN1 | |
| SCHEMBL2367584 | 0.74 | MAPT (0.54) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2367928 | 0.73 | MAPT (0.55) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2368338 | 0.73 | MAPT (0.55) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL15329816 | 0.73 | PTGDR2 (0.48) | POLBMAPTTSHRPTGDR2SMN1; SMN2 | |
| SCHEMBL2367566 | 0.72 | MAPK1 (0.51) | MAPTTSHRMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2368887-A1 | 1, 2, 3-triazole derivatives for use as stearoyl-COA desaturase inhibitors | Glaxosmithkline LLC (US) | 2011-09-28 | — | — | EP | disclosed |