Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKMYT1 | Q99640 | 13/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 4/20 | 0.33 |
| ▸ | MYT1 | Q01538 | 1/20 | 0.33 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23903669 | 0.87 | PKMYT1 (0.60) | PKMYT1CYP2C9CYP3A4CYP2D6EPHB4 | |
| SCHEMBL23903337 | 0.78 | PKMYT1 (0.37) | PKMYT1CYP2C9CYP3A4CYP2D6EPHB4 | |
| SCHEMBL23903348 | 0.78 | PKMYT1 (0.31) | PKMYT1 | |
| SCHEMBL23903506 | 0.77 | PKMYT1 (0.40) | PKMYT1CYP2C9CYP3A4CYP2D6EPHB4 | |
| SCHEMBL23905698 | 0.77 | PKMYT1 (0.37) | PKMYT1CYP2C9CYP3A4CYP2D6EPHB4 | |
| SCHEMBL23905688 | 0.76 | PKMYT1 (0.36) | PKMYT1CYP2C9CYP3A4CYP2D6EPHB4 | |
| SCHEMBL29869546 | 0.76 | PKMYT1 (0.83) | PKMYT1CYP2C9CYP3A4CYP2D6WEE1 | |
| SCHEMBL23888207 | 0.76 | PKMYT1 (0.83) | PKMYT1CYP2C9CYP3A4CYP2D6WEE1 | |
| SCHEMBL24708599 | 0.75 | PKMYT1 (0.41) | PKMYT1CYP2C9CYP3A4CYP2D6WEE1 | |
| SCHEMBL23903339 | 0.75 | PKMYT1 (0.46) | PKMYT1CYP2C9CYP3A4CYP2D6EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022213204-A9 | CARBOXAMIDE PYROLOPYRAZINE AND PYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF MYT1 AND USE THEREOF IN THE TREATMENT OF CANCER | REPARE THERAPEUTICS INC. (CA) | 2023-11-16 | — | — | WO | disclosed |
| WO-2022213204-A1 | COMBINATION THERAPIES INCLUDING MYT1 INHIBITORS | REPARE THERAPEUTICS INC. (CA) | 2022-10-13 | — | — | WO | disclosed |
| WO-2021195782-A1 | METHODS OF USING MYT1 INHIBITORS | REPARE THERAPEUTICS INC. (CA) | 2021-10-07 | — | — | WO | disclosed |
| WO-2021195781-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF PREPARING COMPOUNDS AND OF THEIR USE | REPARE THERAPEUTICS INC. (CA) | 2021-10-07 | — | — | WO | disclosed |