Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 20/20 | 0.58 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21106758 | 0.83 | IRAK4 (0.79) | IRAK4IRAK1KCNH2 | |
| SCHEMBL24606914 | 0.81 | IRAK4 (0.62) | IRAK4IRAK1 | |
| SCHEMBL22835156 | 0.80 | IRAK4 (0.61) | IRAK4IRAK1 | |
| SCHEMBL29502413 | 0.80 | IRAK4 (0.61) | IRAK4IRAK1 | |
| SCHEMBL22849205 | 0.80 | IRAK4 (0.61) | IRAK4IRAK1 | |
| SCHEMBL22849204 | 0.79 | IRAK4 (0.77) | IRAK4 | |
| SCHEMBL29502332 | 0.79 | IRAK4 (0.77) | IRAK4 | |
| SCHEMBL22848830 | 0.79 | IRAK4 (0.67) | IRAK4IRAK1 | |
| SCHEMBL22835162 | 0.79 | IRAK4 (0.77) | IRAK4 | |
| SCHEMBL26346700 | 0.79 | IRAK4 (0.60) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309636-A1 | INDAZOLE AMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309636-A1 | INDAZOLE AMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | IRAK4, IRAK1, IRAK2 | IRAK4 1/4885IRAK1 2/4885KCNH2 4156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.