Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 5/20 | 0.46 |
| ▸ | CDK4 | P11802 | 9/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | CCND1 | P24385 | 4/20 | 0.45 |
| ▸ | CDK1 | P06493 | 3/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.45 |
| ▸ | WEE1 | P30291 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.43 |
| ▸ | CSF1R | P07333 | 5/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30086398 | 1.00 | ACVR1 (0.49) | ACVR1JAK2JAK3CDK4CCNE1 | |
| SCHEMBL23906708 | 0.91 | JAK2 (0.56) | ACVR1JAK2JAK3CDK4CDK2 | |
| SCHEMBL30086462 | 0.91 | JAK2 (0.56) | ACVR1JAK2JAK3CDK4CDK2 | |
| SCHEMBL30086569 | 0.90 | JAK2 (0.47) | ACVR1JAK2JAK3CDK4CDK2 | |
| SCHEMBL23906266 | 0.90 | JAK2 (0.47) | ACVR1JAK2JAK3CDK4CDK2 | |
| SCHEMBL23906917 | 0.90 | JAK2 (0.51) | JAK2JAK3CDK4CDK2CDK1 | |
| SCHEMBL30086450 | 0.90 | JAK2 (0.51) | JAK2JAK3CDK4CDK2CDK1 | |
| SCHEMBL23906269 | 0.88 | WEE1 (0.45) | ACVR1JAK2JAK3CDK4CDK2 | |
| SCHEMBL30086504 | 0.88 | WEE1 (0.45) | ACVR1JAK2JAK3CDK4CDK2 | |
| SCHEMBL25220170 | 0.88 | JAK3 (0.45) | ACVR1JAK2JAK3CDK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2023-12-14 | — | — | US | disclosed |
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2023-12-14 | — | — | US | disclosed |
| US-11673879-B2 | Substituted pyrimidines and methods of use | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-06-13 | — | — | US | disclosed |
| US-11673879-B2 | Substituted pyrimidines and methods of use | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-06-13 | — | — | US | disclosed |
| WO-2021203131-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2021-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11673879-B2 | Substituted pyrimidines and methods of use | ALK, TYMP, ENTPD5 | ACVR1 4/4885JAK2 1187/4885JAK3 1474/4885 |
| US-20230399312-A1 | SUBSTITUTED PYRIMIDINES AND METHODS OF USE | ALK, TYMP, ENTPD5 | ACVR1 4/4885JAK2 1187/4885JAK3 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.