Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amrubicin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 3/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.95 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.95 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.95 |
| ▸ | MEN1 | O00255 | 9/20 | 0.55 |
| ▸ | THRB | P10828 | 9/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.55 |
| ▸ | BLM | P54132 | 8/20 | 0.55 |
| ▸ | RECQL | P46063 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | BRCA1 | P38398 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.55 |
| ▸ | S100A4 | P26447 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | USP2 | O75604 | 4/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amrubicin SCHEMBL10079225 | 0.97 | CHRM1 (1.00) | CHRM1TBXA2RPTGS1ADRA1AMEN1 | |
| Amrubicin SCHEMBL9140 | 0.97 | CHRM1 (1.00) | CHRM1TBXA2RPTGS1ADRA1AMEN1 | |
| Amrubicin SCHEMBL10061868 | 0.97 | CHRM1 (1.00) | CHRM1TBXA2RPTGS1ADRA1AMEN1 | |
| Amrubicin SCHEMBL868435 | 0.97 | CHRM1 (1.00) | CHRM1TBXA2RPTGS1ADRA1AMEN1 | |
| Amrubicin SCHEMBL10080133 | 0.97 | CHRM1 (1.00) | CHRM1TBXA2RPTGS1ADRA1AMEN1 | |
| Amrubicin SCHEMBL6254801 | 0.97 | CHRM1 (1.00) | CHRM1TBXA2RPTGS1ADRA1AMEN1 | |
| Amrubicin SCHEMBL119022 | 0.97 | CHRM1 (1.00) | CHRM1TBXA2RPTGS1ADRA1AMEN1 | |
| Amrubicin SCHEMBL13091911 | 0.97 | CHRM1 (1.00) | CHRM1TBXA2RPTGS1ADRA1AMEN1 | |
| Amrubicin SCHEMBL491010 | 0.96 | CHRM1 (0.98) | CHRM1TBXA2RPTGS1ADRA1AMEN1 | |
| Amrubicin SCHEMBL2524979 | 0.96 | CHRM1 (0.98) | CHRM1TBXA2RPTGS1ADRA1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4135686-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug Inc (US) | 2023-02-22 | — | — | EP | claimed |
| WO-2021211294-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug INC (US) | 2021-10-21 | — | — | WO | claimed |
| US-20210315913-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug, Inc (US) | 2021-10-14 | — | — | US | claimed |
| US-11752165-B2 | Basic chemotherapeutic intratumour injection formulation | US Nano Food & Drug, Inc (US) | 2023-09-12 | — | — | US | disclosed |
| EP-4135686-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug Inc (US) | 2023-02-22 | — | — | EP | disclosed |
| CN-114929213-A | Alkaline chemotherapeutic intratumoral injection composition | 美国纳米食品药品公司 | 2022-08-19 | — | — | CN | disclosed |
| WO-2021211294-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug INC (US) | 2021-10-21 | — | — | WO | disclosed |
| US-20210315913-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug, Inc (US) | 2021-10-14 | — | — | US | disclosed |