Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1773969 | 0.81 | HRH4 (0.79) | HRH4HRH3KCNH2HRH2HRH1 | |
| SCHEMBL1775087 | 0.78 | HRH4 (0.63) | HRH4HRH3KCNH2 | |
| SCHEMBL1776460 | 0.77 | HRH4 (0.61) | HRH4HRH3KCNH2HRH2HRH1 | |
| SCHEMBL1775613 | 0.77 | HRH4 (0.61) | HRH4HRH3KCNH2HRH2HRH1 | |
| SCHEMBL1774578 | 0.77 | HRH4 (0.61) | HRH4HRH3KCNH2HRH2HRH1 | |
| SCHEMBL1778272 | 0.77 | HRH4 (0.61) | HRH4HRH3KCNH2 | |
| SCHEMBL1774126 | 0.77 | HRH4 (0.61) | HRH4HRH3KCNH2HRH2HRH1 | |
| SCHEMBL18601597 | 0.77 | HRH4 (0.61) | HRH4HRH3KCNH2HRH2HRH1 | |
| Water SCHEMBL18789401 | 0.77 | HRH4 (0.57) | HRH4HRH3KCNH2HRH2HRH1 | |
| Water SCHEMBL28865640 | 0.77 | HRH4 (0.57) | HRH4HRH3KCNH2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160960-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2021-10-13 | — | — | EP | disclosed |