Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | RARB | P10826 | 8/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | NR0B2 | Q15466 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 6/20 | 0.38 |
| ▸ | RARG | P13631 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394296 | 0.92 | HDAC11 (0.45) | HDAC11RARBHDAC2LMNAALDH1A1 | |
| SCHEMBL2393173 | 0.91 | HDAC11 (0.42) | HDAC11RARBPTPN11NR0B2HDAC2 | |
| SCHEMBL2390068 | 0.90 | HDAC11 (0.43) | HDAC11RARBPTPN11NR0B2HDAC2 | |
| SCHEMBL2395834 | 0.89 | PTPN11 (0.48) | HDAC11RARBPTPN11NR0B2HDAC2 | |
| SCHEMBL2390729 | 0.89 | HDAC11 (0.44) | HDAC11RARBPTPN11NR0B2HDAC2 | |
| SCHEMBL2391032 | 0.89 | HDAC11 (0.46) | HDAC11RARBHDAC2LMNAALDH1A1 | |
| SCHEMBL2390175 | 0.86 | RARB (0.54) | HDAC11RARBPTPN11NR0B2HDAC2 | |
| SCHEMBL14974248 | 0.85 | HDAC11 (0.43) | HDAC11RARBHDAC2LMNAALDH1A1 | |
| SCHEMBL2393669 | 0.85 | HDAC11 (0.42) | HDAC11RARBHDAC2LMNAALDH1A1 | |
| SCHEMBL6022849 | 0.84 | PTPN11 (0.58) | HDAC11RARBPTPN11NR0B2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |