⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25875169 | 0.77 | AR (0.32) | — | |
| SCHEMBL13676919 | 0.75 | KMT2A (0.33) | — | |
| SCHEMBL17187791 | 0.74 | — | — | |
| SCHEMBL17586558 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL2937548 | 0.72 | — | — | |
| SCHEMBL758682 | 0.70 | — | — | |
| SCHEMBL11986 | 0.67 | — | — | |
| SCHEMBL10619149 | 0.67 | — | — | |
| SCHEMBL14890033 | 0.67 | — | — | |
| SCHEMBL3170665 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584758-B2 | RIP1K inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210317135-A1 | RIP1K INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2021-10-14 | — | — | US | disclosed |