Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL5164335 | 0.98 | CYP3A4 (0.39) | CYP3A4TSHRPIK3CAS100BESR1 | |
| Ethylene Glycol SCHEMBL6233877 | 0.91 | CYP3A4 (0.40) | CYP3A4TSHRPIK3CAS100BESR1 | |
| SCHEMBL33509 | 0.87 | CYP3A4 (0.50) | CYP3A4TSHRPIK3CAALDH1A1TDP1 | |
| Methyl Alcohol SCHEMBL27917657 | 0.85 | CYP3A4 (0.43) | CYP3A4TSHRPIK3CAALDH1A1TDP1 | |
| Fluoride SCHEMBL1502751 | 0.85 | CYP3A4 (0.48) | CYP3A4TSHRPIK3CAALDH1A1TDP1 | |
| Water SCHEMBL9259705 | 0.85 | CYP3A4 (0.48) | CYP3A4TSHRPIK3CAALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL553599 | 0.85 | CYP3A4 (0.48) | CYP3A4TSHRPIK3CAALDH1A1TDP1 | |
| Bromide SCHEMBL128888 | 0.85 | CYP3A4 (0.48) | CYP3A4TSHRPIK3CAALDH1A1TDP1 | |
| SCHEMBL15346025 | 0.85 | CYP3A4 (0.48) | CYP3A4TSHRPIK3CAALDH1A1TDP1 | |
| Iodide SCHEMBL1157672 | 0.85 | CYP3A4 (0.48) | CYP3A4TSHRPIK3CAALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10633519-B2 | Storage-stable polyurethane prepregs and mouldings produced therefrom composed of a polyurethane composition with liquid resin components | EVONIK OPERATIONS GMBH (DE) | 2020-04-28 | — | — | US | claimed |
| EP-2411439-B1 | PREPEGS AND MOLDED BODIES PRODUCED THEREOF AT LOW TEMPERATURE | EVONIK DEGUSSA GMBH (DE) | 2016-11-16 | — | — | EP | claimed |
| EP-2188320-B1 | DUAL CURE FORMULATIONS WITH COMPONENTS COMPRISING URETDIONE GROUPS | EVONIK DEGUSSA GMBH (DE) | 2014-05-14 | — | — | EP | claimed |
| US-20140087613-A1 | STORAGE-STABLE POLYURETHANE PREPREGS AND MOULDINGS PRODUCED THEREFROM COMPOSED OF A POLYURETHANE COMPOSITION WITH LIQUID RESIN COMPONENTS | EVONIK DEGUSSA GMBH (DE) | 2014-03-27 | — | — | US | claimed |
| US-8455090-B2 | Prepegs and molded bodies produced thereof at low temperature | EVONIK DEGUSSA GMBH (DE) | 2013-06-04 | — | — | US | claimed |
| US-20120003890-A1 | PREPEGS AND MOLDED BODIES PRODUCED THEREOF AT LOW TEMPERATURE | EVONIK DEGUSSA GMBH (DE) | 2012-01-05 | — | — | US | claimed |
| US-20100227942-A1 | DUAL-CURE FORMULATIONS WITH COMPONENTS CONTAINING URETDIONE GROUPS | EVONIK DEGUSSA GMBH (DE) | 2010-09-09 | — | — | US | claimed |
| EP-1560833-B1 | PREPARATION OF CODEINE FROM MORPHINE | MALLINCKRODT INTERNAT CORP (US) | 2007-03-14 | — | — | EP | claimed |
| EP-1560833-A2 | PREPARATION OF CODEINE FROM MORPHINE | Mallinckrodt International Corporation (US) | 2005-08-10 | — | — | EP | claimed |
| WO-2004037826-A2 | PREPARATION OF CODEINE FROM MORPHINE | MALLINCKRODT INC. (US) | 2004-05-06 | — | — | WO | claimed |
| US-6579985-B1 | Preparation of codeine from morphine | MALLINCKRODT INC. | 2003-06-17 | — | — | US | claimed |
| US-10633519-B2 | Storage-stable polyurethane prepregs and mouldings produced therefrom composed of a polyurethane composition with liquid resin components | EVONIK OPERATIONS GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-10029427-B2 | Process for the production of storage-stable polyurethane prepregs and mouldings produced therefrom from dissolved polyurethane composition | EVONIK DEGUSSA GMBH (DE) | 2018-07-24 | — | — | US | disclosed |
| US-20140087613-A1 | STORAGE-STABLE POLYURETHANE PREPREGS AND MOULDINGS PRODUCED THEREFROM COMPOSED OF A POLYURETHANE COMPOSITION WITH LIQUID RESIN COMPONENTS | EVONIK DEGUSSA GMBH (DE) | 2014-03-27 | — | — | US | disclosed |
| US-20130303042-A1 | PROCESS FOR THE PRODUCTION OF STORAGE-STABLE POLYURETHANE PREPREGS AND MOULDINGS PRODUCED THEREFROM FROM DISSOLVED POLYURETHANE COMPOSITION | EVONIK DEGUSSA GMBH (DE) | 2013-11-14 | — | — | US | disclosed |
| EP-1560833-B1 | PREPARATION OF CODEINE FROM MORPHINE | MALLINCKRODT INTERNAT CORP (US) | 2007-03-14 | — | — | EP | disclosed |
| EP-1560833-A2 | PREPARATION OF CODEINE FROM MORPHINE | Mallinckrodt International Corporation (US) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004037826-A2 | PREPARATION OF CODEINE FROM MORPHINE | MALLINCKRODT INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| US-6579985-B1 | Preparation of codeine from morphine | MALLINCKRODT INC. | 2003-06-17 | — | — | US | disclosed |
| EP-0268710-A1 | Improved process for the preparation of codeine from morphine | Council of Scientific and Industrial Research (IN) | 1988-06-01 | — | — | EP | disclosed |