Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.55 |
| ▸ | GSK3B | P49841 | 17/20 | 0.55 |
| ▸ | WNT1 | P04628 | 10/20 | 0.55 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20227159 | 0.90 | DYRK1A (0.66) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916074 | 0.88 | DYRK1A (0.59) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916597 | 0.87 | DYRK1A (0.55) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916146 | 0.87 | GSK3B (0.57) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916657 | 0.80 | GSK3B (0.60) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19546602 | 0.79 | DYRK1A (0.73) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916606 | 0.79 | DYRK1A (0.57) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19546669 | 0.79 | DYRK1A (0.80) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19546557 | 0.78 | DYRK1A (0.59) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916625 | 0.77 | DYRK1A (0.81) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |